악골에서 발생한 미만성 거대 B세포 림프종의 조기 진단 중요성
The Importance of Early Diagnosis of Diffuse Large B-cell Lymphoma in the Jaw: Case Reports
오지석, 권익재, 명훈,
소속 상세정보
오지석 ( Oh Ji-Seok ) - Department of Oral and Maxillofacial Suregry, College of Dentistry, Seoul National University
권익재 ( Kwon Ik-Jae ) - Seoul National University Dental Hospital Department of Oral and Maxillofacial Surgery
명훈 ( Myoung Hoon ) - Seoul National University Dental Hospital Department of Oral and Maxillofacial Surgery
Abstract
Lymphoma, which accounts for 3.5% of all oral cancers, is further divided into Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL). NHL accounts for 96% of lymphomas, and diffuse large B-cell lymphoma (DLBCL) is the most common subtype accounting for 32% of NHL. In the oral cavity, extra-nodal non-Hodgkin's lymphoma may develop in the dentoalveolar region of the maxilla or mandible. It can also mimic inflammatory lesions that occur around periodontal tissues, such as periapical granuloma and chronic osteomyelitis. Misdiagnosis of jaw lymphoma can delay appropriate treatments and worsen the prognosis. Therefore, to avoid delay in diagnosis, clinicians should identify the possible malignancy based on unusual symptoms, clinical findings, radiographic examinations, and histopathological evaluation. We present two cases of DLBCL in the right posterior mandible of a 64-year-old man who was initially misdiagnosed as acute apical abscess and in the right posterior maxilla of an 81-year-old woman who was initially misdiagnosed as chronic periodontitis. These cases demonstrate that it is important for both pathologists and clinicians to consider malignant lesions such as lymphomas in the differential diagnosis of apical radiolucency.
키워드
Non-Hodgkin’s lymphoma ; Diffuse large B-cell lymphoma ; Early diagnosis
원문 및 링크아웃 정보
등재저널 정보